The old residence of Zhou Enlai is located on the border of Quxiang Lane and Western Hongguang Lane in Huai'an City, Jiangshu Province.

Zhou (1898-1976), whose ancestral home is in Shaoxing of Zhejiang Province, was an important founder of the New China. He once acted as premier and foreign minister of the People's Republic of China, vice-president of China People's Revolutionary Military Commission, president of the National Committee of China People's Political Consultative Conference and vice-president of the Central Committee of the Communist Party of China.

The two compounds of the old residence were bought by Zhou's grandfather and his uncle respectively when they both moved to Huai'an from their ancestral home in Zhejiang. Originally, the residence had 31 rooms with three rows of 12 houses in the eastern compound and three rows of 19 houses in the western compound. Zhou was born in the third room from the west in the northern part of the western compound on March 5, 1898 and spent his childhood and early youth there. The two rooms from the east in the northern part of the western compound served as Zhou's study rooms. In 1910, 12-year-old Zhou left Huai'an for Northeastern China to study.