St. Dominic's Church is located at the junction of Senado Square and Dominic's Square. Ascending from the base of Mount Hill from this urban piazza along Palha Street, the bluestone cobbled road leads to the grand fa?ade of the Ruins of St. Paul's, with Mount Fortress to the side of it.

Behind the majestic church front is the miniature Na Tcha Temple and Section of the Old City Walls. Further down the hill, the linear route ends at St. Anthony's Church, the Casa Garden and the Protestant Cemetery. Standing on the highest hill of Macao Guia Hill, Guia Fortress, Chapel and Lighthouse are visible along the skyline of the peninsula.